A hybrid mammalian cell cycle model

Vincent Noël
(Université de Rennes 1)
Sergey Vakulenko
(Saint Petersburg State University of Technology and Design)
Ovidiu Radulescu
(Université de Montpellier 2)

Hybrid modeling provides an effective solution to cope with multiple time scales dynamics in systems biology. Among the applications of this method, one of the most important is the cell cycle regulation. The machinery of the cell cycle, leading to cell division and proliferation, combines slow growth, spatio-temporal re-organisation of the cell, and rapid changes of regulatory proteins concentrations induced by post-translational modifications. The advancement through the cell cycle comprises a well defined sequence of stages, separated by checkpoint transitions. The combination of continuous and discrete changes justifies hybrid modelling approaches to cell cycle dynamics. We present a piecewise-smooth version of a mammalian cell cycle model, obtained by hybridization from a smooth biochemical model. The approximate hybridization scheme, leading to simplified reaction rates and binary event location functions, is based on learning from a training set of trajectories of the smooth model. We discuss several learning strategies for the parameters of the hybrid model.

In Thao Dang and Carla Piazza: Proceedings Second International Workshop on Hybrid Systems and Biology (HSB 2013), Taormina, Italy, 2nd September 2013, Electronic Proceedings in Theoretical Computer Science 125, pp. 68–83.
Published: 27th August 2013.

ArXived at: http://dx.doi.org/10.4204/EPTCS.125.5 bibtex PDF
References in reconstructed bibtex, XML and HTML format (approximated).
Comments and questions to: eptcs@eptcs.org
For website issues: webmaster@eptcs.org