Analysis of the spatial and dynamical properties of a multiscale model of intestinal crypts

Giulio Caravagna
(Dipartimento di Informatica, Sistemistica e Comunicazione, Università degli Studi di Milano-Bicocca.)
Alex Graudenzi
(Dipartimento di Informatica, Sistemistica e Comunicazione, Università degli Studi di Milano-Bicocca.)
Marco Antoniotti
(Dipartimento di Informatica, Sistemistica e Comunicazione, Università degli Studi di Milano-Bicocca.)
Giovanni de Matteis
(Department of Mathematics and Information Sciences, Northumbria University, Pandon Building, Camden Street, Newcastle Upon Tyne, NE2 1XE, England, U.K.)

The preliminary analyses on a multiscale model of intestinal crypt dynamics are here presented. The model combines a morphological model, based on the Cellular Potts Model (CPM), and a gene regulatory network model, based on Noisy Random Boolean Networks (NRBNs). Simulations suggest that the stochastic differentiation process is itself sufficient to ensure the general homeostasis in the asymptotic states, as proven by several measures.

In Alex Graudenzi, Giulio Caravagna, Giancarlo Mauri and Marco Antoniotti: Proceedings Wivace 2013 - Italian Workshop on Artificial Life and Evolutionary Computation (Wivace 2013), Milan, Italy, July 1-2, 2013, Electronic Proceedings in Theoretical Computer Science 130, pp. 79–82.
Published: 30th September 2013.

ArXived at: http://dx.doi.org/10.4204/EPTCS.130.12 bibtex PDF
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